Hydroquinone

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Hydroquinone is a widely used ingredient in cosmetics, personal care, and skincare formulations. Depending on its function, it may serve as a moisturizer, preservative, emulsifier, or active ingredient to enhance the overall effectiveness and performance of a product.

Hydroquinone (Wikipedia)

Hydroquinone, also known as benzene-1,4-diol or quinol, is an aromatic organic compound that is a type of phenol, a derivative of benzene, having the chemical formula C6H4(OH)2. It has two hydroxyl groups bonded to a benzene ring in a para position. It is a white granular solid. Substituted derivatives of this parent compound are also referred to as hydroquinones. The name "hydroquinone" was coined by Friedrich Wöhler in 1843.

Hydroquinone
Hydroquinone
Hydroquinone
Names
Preferred IUPAC name
Benzene-1,4-diol
Other names
Hydroquinone
Idrochinone
Quinol
4-Hydroxyphenol
1,4-Dihydroxybenzene
p-Dihydroxybenzene
p-Benzenediol
Identifiers
3D model (JSmol)
605970
ChEBI
ChEMBL
ChemSpider
DrugBank
ECHA InfoCard 100.004.199 Edit this at Wikidata
EC Number
  • 204-617-8
2742
KEGG
RTECS number
  • MX3500000
UNII
UN number 3077, 2662
  • InChI=1S/C6H6O2/c7-5-1-2-6(8)4-3-5/h1-4,7-8H checkY
    Key: QIGBRXMKCJKVMJ-UHFFFAOYSA-N checkY
  • InChI=1/C6H6O2/c7-5-1-2-6(8)4-3-5/h1-4,7-8H
    Key: QIGBRXMKCJKVMJ-UHFFFAOYAX
  • c1cc(ccc1O)O
Properties
C6H6O2
Molar mass 110.112 g·mol−1
Appearance White solid
Density 1.3 g cm−3, solid
Melting point 172 °C (342 °F; 445 K)
Boiling point 287 °C (549 °F; 560 K)
5.9 g/100 mL (15 °C)
Vapor pressure 10−5 mmHg (20 °C)
Acidity (pKa) 9.9
−64.63×10−6 cm3/mol
Structure
1.4±0.1 D
Pharmacology
D11AX11 (WHO)
Hazards
GHS labelling:
GHS05: CorrosiveGHS07: Exclamation markGHS08: Health hazardGHS09: Environmental hazard
Danger
H302, H317, H318, H341, H351, H400
P201, P202, P261, P264, P270, P272, P273, P280, P281, P301+P312, P302+P352, P305+P351+P338, P308+P313, P310, P321, P330, P333+P313, P363, P391, P405, P501
NFPA 704 (fire diamond)
NFPA 704 four-colored diamondHealth 2: Intense or continued but not chronic exposure could cause temporary incapacitation or possible residual injury. E.g. chloroformFlammability 1: Must be pre-heated before ignition can occur. Flash point over 93 °C (200 °F). E.g. canola oilInstability (yellow): no hazard codeSpecial hazards (white): no code
2
1
Flash point 165 °C (329 °F; 438 K)
Lethal dose or concentration (LD, LC):
490 mg/kg (mammal, oral)
245 mg/kg (mouse, oral)
200 mg/kg (rabbit, oral)
320 mg/kg (rat, oral)
550 mg/kg (guinea pig, oral)
200 mg/kg (dog, oral)
70 mg/kg (cat, oral)
NIOSH (US health exposure limits):
PEL (Permissible)
TWA 2 mg/m3
REL (Recommended)
C 2 mg/m3 [15-minute]
IDLH (Immediate danger)
50 mg/m3
Related compounds
Related benzenediols
Pyrocatechol
Resorcinol
Related compounds
1,4-benzoquinone
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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In 2022, it was the 268th most commonly prescribed medication in the United States, with more than 900,000 prescriptions.

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