Glycyrrhetinic acid

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Glycyrrhetinic acid is a widely used ingredient in cosmetics, personal care, and skincare formulations. Depending on its function, it may serve as a moisturizer, preservative, emulsifier, or active ingredient to enhance the overall effectiveness and performance of a product.

Glycyrrhetinic acid (Wikipedia)

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Find sources: "Enoxolone" – news · newspapers · books · scholar · JSTOR (December 2015) (Learn how and when to remove this message)

Enoxolone (INN, BAN; also known as glycyrrhetinic acid or glycyrrhetic acid) is a pentacyclic triterpenoid derivative of the beta-amyrin type obtained from the hydrolysis of glycyrrhizic acid, which was obtained from the herb liquorice.

Enoxolone
Clinical data

Trade names	Arthrodont, PruClair
AHFS/Drugs.com	International Drug Names
Routes of administration	Oral, topical
ATC code	D03AX10 (WHO)
Legal status
Legal status	US: ℞-only
Identifiers
IUPAC name (2S,4aS,6aS,6bR,8aR,10S,12aS,12bR,14bR)-10-hydroxy-2,4a,6a,6b,9,9,12a-heptamethyl-13-oxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-2-carboxylic acid
CAS Number	471-53-4
PubChem CID	10114
DrugBank	DB13089
ChemSpider	9710
UNII	P540XA09DR
KEGG	D00156
ChEBI	CHEBI:30853
ChEMBL	ChEMBL230006
CompTox Dashboard (EPA)	DTXSID9020669
ECHA InfoCard	100.006.769
Chemical and physical data
Formula	C₃₀H₄₆O₄
Molar mass	470.694 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES O=C(O)[C@]5(C)C[C@H]4/C3=C/C(=O)[C@H]1[C@](CC[C@@H]2[C@]1(C)CC[C@H](O)C2(C)C)(C)[C@]3(C)CC[C@@]4(C)CC5
InChI InChI=1S/C30H46O4/c1-25(2)21-8-11-30(7)23(28(21,5)10-9-22(25)32)20(31)16-18-19-17-27(4,24(33)34)13-12-26(19,3)14-15-29(18,30)6/h16,19,21-23,32H,8-15,17H2,1-7H3,(H,33,34)/t19-,21-,22-,23+,26+,27-,28-,29+,30+/m0/s1 Key:MPDGHEJMBKOTSU-YKLVYJNSSA-N

The substance has a sweet taste, so it is used in flavoring to mask the bitter taste of drugs like aloe and quinine. It may have some anti-inflammatory activities. One of its metabolites is responsible for the blood pressure-increasing effect of liquorice.

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