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Sodium ascorbate

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Sodium ascorbate is a widely used ingredient in cosmetics, personal care, and skincare formulations. Depending on its function, it may serve as a moisturizer, preservative, emulsifier, or active ingredient to enhance the overall effectiveness and performance of a product.

Sodium ascorbate (Wikipedia)
"E301" redirects here. For the Japanese train, see EV-E301 series.

Sodium ascorbate is one of a number of mineral salts of ascorbic acid (vitamin C). The molecular formula of this chemical compound is C6H7NaO6. As the sodium salt of ascorbic acid, it is known as a mineral ascorbate. It has not been demonstrated to be more bioavailable than any other form of vitamin C supplement.

Sodium l-ascorbate
Names
IUPAC name
Sodium (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2H-furan-3-olate
Other names
Sodascorbate; Monosodium ascorbate; E301
Identifiers
3D model (JSmol)
ChEBI
ChEMBL
ECHA InfoCard 100.004.661 Edit this at Wikidata
EC Number
  • 205-126-1
E number E301 (antioxidants, ...)
KEGG
RTECS number
  • CI7671000
UNII
  • InChI=1S/C6H8O6.Na/c7-1-2(8)5-3(9)4(10)6(11)12-5;/h2,5,7-10H, 1H2;/q;+1/p-1/t2-,5+;/m0./s1
  • OC1=C([O-])[C@]([C@@H](O)CO)([H])OC1=O.[Na+]
Properties
C6H7NaO6
Molar mass 198.106 g·mol−1
Appearance minute white to yellow crystals
Odor odorless
Density 1.66 g/cm3
Melting point 218 °C (424 °F; 491 K) (decomposes)
62 g/100 mL (25 °C)
78 g/100 mL (75 °C)
Solubility very slightly soluble in alcohol
insoluble in chloroform, ether
Hazards
NFPA 704 (fire diamond)
NFPA 704 four-colored diamondHealth 0: Exposure under fire conditions would offer no hazard beyond that of ordinary combustible material. E.g. sodium chlorideFlammability 0: Will not burn. E.g. waterInstability 0: Normally stable, even under fire exposure conditions, and is not reactive with water. E.g. liquid nitrogenSpecial hazards (white): no code
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Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Sodium ascorbate normally provides 131 mg of sodium per 1,000 mg of ascorbic acid (1,000 mg of sodium ascorbate contains 889 mg of ascorbic acid and 111 mg of sodium).

As a food additive, it has the E number E301 and is used as an antioxidant and an acidity regulator. It is approved for use as a food additive in the EU, USA, Australia, and New Zealand.

In in vitro studies, sodium ascorbate has been found to produce cytotoxic effects in various malignant cell lines, which include melanoma cells that are particularly susceptible.

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