Picaridin

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Picaridin is a widely used ingredient in cosmetics, personal care, and skincare formulations. Depending on its function, it may serve as a moisturizer, preservative, emulsifier, or active ingredient to enhance the overall effectiveness and performance of a product.

Picaridin (Wikipedia)

Icaridin, also known as picaridin, is an insect repellent which can be used directly on skin or clothing. It has broad efficacy against various arthropods such as mosquitos, ticks, gnats, flies and fleas, and is almost colorless and odorless. A study performed in 2010 showed that picaridin spray and cream at the 20% concentration provided 12 hours of protection against ticks. Unlike DEET, icaridin does not dissolve plastics, synthetics or sealants, is odorless and non-greasy and presents a lower risk of toxicity when used with sunscreen, as it may reduce skin absorption of both compounds.

Icaridin
Names
Preferred IUPAC name
Butan-2-yl 2-(2-hydroxyethyl)piperidine-1-carboxylate
Other names
  • KBR 3023
  • Hydroxyethyl isobutyl piperidine carboxylate
  • sec-Butyl 2-(2-hydroxyethyl)piperidine-1-carboxylate
Identifiers
3D model (JSmol)
ChEMBL
ChemSpider
ECHA InfoCard 100.102.177 Edit this at Wikidata
UNII
  • InChI=1S/C12H23NO3/c1-3-10(2)16-12(15)13-8-5-4-6-11(13)7-9-14/h10-11,14H,3-9H2,1-2H3 checkY
    Key: QLHULAHOXSSASE-UHFFFAOYSA-N checkY
  • InChI=1/C12H23NO3/c1-3-10(2)16-12(15)13-8-5-4-6-11(13)7-9-14/h10-11,14H,3-9H2,1-2H3
    Key: QLHULAHOXSSASE-UHFFFAOYAQ
  • O=C(OC(C)CC)N1C(CCO)CCCC1
Properties
C12H23NO3
Molar mass 229.320 g·mol−1
Appearance colorless liquid
Odor odorless
Density 1.07 g/cm3
Melting point −170 °C (−274 °F; 103 K)
Boiling point 296 °C (565 °F; 569 K)
0.82 g/100 mL
Solubility 752 g/100mL (acetone)
1.4717
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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The name picaridin was proposed as an International Nonproprietary Name (INN) to the World Health Organization (WHO), but the official name that has been approved by the WHO is icaridin. The chemical is part of the piperidine family, along with many pharmaceuticals and alkaloids such as piperine, which gives black pepper its spicy taste.

Trade names include Bayrepel and Saltidin among others. The compound was developed by the German chemical company Bayer in the 1980s and was given the name Bayrepel. In 2005, Lanxess AG and its subsidiary Saltigo GmbH were spun off from Bayer and the product was renamed Saltidin in 2008.

Having been sold in Europe (where it is the best-selling insect repellent) since 1998, on 23 July 2020, icaridin was approved again by the EU Commission for use in repellent products. The approval entered into force on 1 February 2022 and is valid for ten years.

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